Refinement of the Pathogenic T Cell Receptor Motif Suggests Type 17 CD8+ T Cells Initiate HLA-B*27-associated Autoimmunity.
Risch I · 2026 · bioRxiv : the preprint server for biology
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What this paper found
A specific family of killer T cells that recognise HLA-B27 was found in people with axial spondyloarthritis, uveitis and psoriatic arthritis but not healthy controls, and these cells appear to switch into an IL-17-producing mode in the gut. It is a direct line from the HLA-B27 gene, through the gut, to the inflammation that IL-17 drugs block, in one set of cells.
Why this is on the map
Ties three threads together with a single cell type; a preprint, so not yet peer reviewed.
On the map under these threads
DOI: 10.64898/2026.09.18.752092 · opens in a new tab. The full paper is on the publisher’s site, not here.
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