A disease-associated gene desert directs macrophage inflammation through ETS2
Stankey · 2024 · Nature
What this paper found
Identified a single 'switch' gene called ETS2, sitting on chromosome 21, that turns immune cells inflammatory across AS, IBD, and several other related diseases. Because no current drug targets ETS2, this points to a treatment direction beyond what's already available with TNF and IL-17 blockers.
Why this is on the map
Landmark paper. Names a master switch that explains why the same chromosome region keeps showing up across different inflammatory diseases.
On the map under these threads
DOI: 10.1038/s41586-024-07501-1· opens in a new tab. The full paper is on the publisher’s site, not here.
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