Research map
Eight mechanistic threads · papers added monthly
Genetics and susceptibility
HLA-B27 biology, ERAP1/ERAP2, ETS2, IL23R, GWAS hits, polymorphisms, twin and family studies.
No papers added to this thread yet. The first additions land through the contribution form (Phase 1E) and the monthly literature tracker (Phase 1F).
Gut–joint axis and microbiome
Dysbiosis, gut barrier, subclinical IBD, microbiome interventions, IBD–AS overlap.
No papers added to this thread yet. The first additions land through the contribution form (Phase 1E) and the monthly literature tracker (Phase 1F).
IL-23 / Th17 / IL-17 pathway
IL-17A/F, IL-23, Th17 differentiation, ROR-γt, secukinumab / ixekizumab / bimekizumab biology.
No papers added to this thread yet. The first additions land through the contribution form (Phase 1E) and the monthly literature tracker (Phase 1F).
TNF biology and TNF blockers
TNF-α, TNF receptors, anti-TNF mechanisms, immunogenicity, head-to-head trials.
No papers added to this thread yet. The first additions land through the contribution form (Phase 1E) and the monthly literature tracker (Phase 1F).
JAK–STAT signalling
JAK1/2/3, STAT3, oral JAK inhibitor trials and safety, cycling after biologic failure.
No papers added to this thread yet. The first additions land through the contribution form (Phase 1E) and the monthly literature tracker (Phase 1F).
T-cell and cellular immunology
CD8 cytotoxic T cells, MAIT cells, regulatory T cells, ILCs, single-cell studies.
No papers added to this thread yet. The first additions land through the contribution form (Phase 1E) and the monthly literature tracker (Phase 1F).
Imaging and biomarkers
MRI sacroiliitis, low-dose CT, novel biomarkers (calprotectin, CXCL9), radiographic progression.
No papers added to this thread yet. The first additions land through the contribution form (Phase 1E) and the monthly literature tracker (Phase 1F).
Treatment response and outcomes
BASDAI/ASDAS, drug cycling, tapering, remission, patient-reported outcomes, real-world evidence.
No papers added to this thread yet. The first additions land through the contribution form (Phase 1E) and the monthly literature tracker (Phase 1F).
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