HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation
Huang · 2026 · Gut Microbes
What this paper found
Shows that HLA-B27, the gene most strongly linked to AS, reshapes which bacteria live in the gut and how the body handles certain amino acids, which in turn activates the inflammatory immune cells driving the disease. Suggests targeting the gut and these metabolic changes could become a real treatment route.
Why this is on the map
Bridges three threads at once, HLA-B27 genetics, the gut-immune axis, and macrophage activation.
On the map under these threads
DOI: 10.1080/19490976.2026.2630561· opens in a new tab. The full paper is on the publisher’s site, not here.
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