Macrophages: subtypes, distribution, polarization, immunomodulatory functions, and therapeutics
Peng · 2025 · MedComm
What this paper found
Comprehensive review of macrophage subtypes, distribution, polarisation states, and therapeutic targeting. NF-κB and p38 MAPK pathway hijacking drives the maladaptive M1 shift, with links to DNA damage and senescence-associated secretory phenotype accumulation.
Why this is on the map
Connects to the ETS2/Stankey story from a different mechanistic entry point, same destination, different route.
On the map under these threads
DOI: 10.1002/mco2.70304· opens in a new tab. The full paper is on the publisher’s site, not here.
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