The role of ETS2 in macrophage inflammation
Stankey · 2025 · DNA and Cell Biology
What this paper found
Direct follow-up to the 2024 Nature paper. Shows that ETS2 turns on several inflammatory signals at once, TNF, IL-23, IL-1β, and TL1A, the same signals current biologic drugs target one at a time.
Why this is on the map
Argues a single ETS2-targeting drug could replace combination biologic therapy. Speculative, but the strongest single argument for ETS2 work.
On the map under these threads
DOI: 10.1089/dna.2025.0064· opens in a new tab. The full paper is on the publisher’s site, not here.
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