Lower HLA-B27 positivity and heterogeneous late-onset case proportions across axial spondyloarthritis cohorts: a systematic review and meta-analysis.
Yan F · 2026 · Rheumatology international
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What this paper found
Pooling 42 studies, about one in eight people with axial spondyloarthritis first had symptoms after age 45, and those late starters were half as likely to carry the HLA-B27 gene. If you were diagnosed later in life and tested HLA-B27 negative, that is a recognised pattern, not an oddity.
Why this is on the map
Quantifies a late-onset, HLA-B27-negative subgroup that the genetics thread otherwise treats as the exception.
On the map under this thread
DOI: 10.1007/s00296-026-06310-1 · opens in a new tab. The full paper is on the publisher’s site, not here.
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