inflamed.communityinflamed.community

Bimekizumab Long-Term Safety and Efficacy Across the Spectrum of Axial Spondyloarthritis Over 3 Years: Results From 2 Phase III Studies.

Baraliakos X · 2026 · The Journal of rheumatology

Reading the original? How to read a paper.

What this paper found

Three years of bimekizumab (Bimzelx) in 574 people across the whole axial spondyloarthritis spectrum showed no deaths or major heart events, with mild thrush-type fungal infections the main side effect and rates falling by year three. Benefits held steady, so for people weighing a long-term IL-17 drug the safety picture so far is reassuring.

Why this is on the map

Longest safety follow-up yet for dual IL-17A/F blockade, extending the two-year data already on the map.

On the map under this thread

Read the paper at the source →

DOI: 10.3899/jrheum.2026-0113 · opens in a new tab. The full paper is on the publisher’s site, not here.

Related papers on the board

Papers sharing one or more threads with this one.

Stankey · 2024
Study

A disease-associated gene desert directs macrophage inflammation through ETS2

Nature

Identified a single 'switch' gene called ETS2, sitting on chromosome 21, that turns immune cells inflammatory across AS, IBD, and several other related diseases. Because no current drug targets ETS2, this points to a treatment direction beyond what's already available with TNF and IL-17 blockers.

ETS2 / Functional GenomicsMacrophage M1 PolarisationIL-23 / IL-17 Axis
Lobiuc · 2025
Review

Gut microbiota and ankylosing spondylitis: current insights and future challenges

Microbial Cell

Comprehensive review of how gut bacterial imbalance disrupts the IL-23/IL-17 inflammatory pathway and weakens the intestinal barrier in AS. Identifies the lack of standardised methodology and large cohorts as the bottleneck for translating this into treatments.

Gut–Immune AxisIL-23 / IL-17 Axis
, · 2025
Study

Dysbiosis of Gut Microbiota in Ankylosing Spondylitis Patients

Dove Medical Press

Confirms that intestinal dysfunction precedes or amplifies systemic inflammation in AS. Frames gut microbiota as the convergence point where genetic, immune, and microbial factors meet.

Gut–Immune AxisIL-23 / IL-17 Axis
Deng · 2026
Review

Current status and emerging trends in biological therapies for ankylosing spondylitis: a bibliometric analysis (2004–2024)

Medicine (LWW)

Bibliometric analysis of biological therapies for AS over 2004-2024. Confirms three pillars, TNF, IL-17, and JAK inhibitors, and a persistent inadequate response in a meaningful subset of patients across all three classes.

JAK–STAT PathwayTNF-α InhibitionIL-23 / IL-17 Axis