Impact of bimekizumab on CANDEN spinal MRI inflammation & structural lesions in radiographic axial spondyloarthritis: 2-year phase 3 results.
Maksymowych WP · 2026 · Rheumatology (Oxford, England)
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What this paper found
In 102 people with radiographic axial spondyloarthritis scanned repeatedly over two years on bimekizumab (Bimzelx), spinal inflammation on MRI fell sharply by 16 weeks and stayed down, fat lesions rose a little early then stopped changing, and erosion and new bone barely moved. The inflammation the drug is aimed at clears quickly and the structural damage that worries people most showed minimal change over two years.
Why this is on the map
Detailed spinal MRI follow-up for dual IL-17A/F blockade; pairs with the sacroiliac and X-ray paper from the same trials.
On the map under these threads
DOI: 10.1093/rheumatology/keag484 · opens in a new tab. The full paper is on the publisher’s site, not here.
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