Association between type 2 diabetes and short-term clinical response to TNF inhibitors in patients with ankylosing spondylitis: a propensity score-matched retrospective cohort study.
Yang Z · 2026 · Clinical rheumatology
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What this paper found
In a single-centre study of people with ankylosing spondylitis starting a TNF blocker, those with type 2 diabetes were far less likely to respond in the short term, 20 percent versus 75 percent in the matched comparison. The authors are careful to call it a signal rather than a proof, since blood sugar control and weight were not fully accounted for, but if you have both conditions it is a conversation worth having before judging a drug a failure.
Why this is on the map
First look at diabetes as a predictor of TNF response in AS; small and retrospective, flagged as hypothesis-generating by its own authors.
On the map under these threads
DOI: 10.1007/s10067-026-08346-x · opens in a new tab. The full paper is on the publisher’s site, not here.
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