Reduction of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy.
Pacheco A · 2026 · ACR open rheumatology
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What this paper found
Among people who did not respond to secukinumab (Cosentyx), those whose IL-17-producing T cells had fallen during treatment went on to respond to either a higher dose or a switch to a TNF blocker, while those whose cells had not changed failed all three options. A blood test during the first biologic might one day predict whether switching is worth it.
Why this is on the map
Small exploratory study, but the first to link immune-cell changes on one biologic to response on the next.
On the map under these threads
DOI: 10.1002/acr2.90093 · opens in a new tab. The full paper is on the publisher’s site, not here.
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