Plasma Proteomics Identifies Molecular Signatures and Biomarkers Associated with High Structural Damage in Ankylosing Spondylitis
Sun Tiantian · 2026 · Arthritis & Rheumatology
Reading the original? How to read a paper.
What this paper found
Measuring hundreds of blood proteins in people with ankylosing spondylitis, researchers found a five-protein signature, driven by platelet and tissue-remodelling proteins rather than classic inflammation markers, that identified those with heavy structural damage with high accuracy in a separate validation group. Bone damage in AS seems to run partly on a different track from inflammation, and a blood test for it looks feasible.
Why this is on the map
Supports the emerging view that fusion and inflammation are partly separate processes, echoed by the stem-cell and EXTL3 papers.
On the map under this thread
DOI: 10.1002/art.70353 · opens in a new tab. The full paper is on the publisher’s site, not here.
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